VC Firms in the US
We've mapped 20 of the most active VC firms in the US, with cheques $25K–$3B.
- Pre-seed8
- Seed18
- Series A17
- Series B13
- Series C+5
We've mapped 20 of the most active VC firms investing in the US — ranked by how recently and how thoroughly each profile has been verified. Cheque sizes across this segment run $25K–$3B.
Not every one of these VC firms is a fit for every round — they differ on stage, cheque size, and sector focus, and the best-known name is rarely the best match. 20 of these profiles have been verified in the last review pass. Sign in to see each investor's full thesis, cheque range, and how closely they fit your specific company.
M12
Microsoft's venture capital fund, investing in seed through Series B companies in AI apps, security for AI, AI cloud infrastructure, AI data ops and models, … Sign in to see full profile →
TTV Capital
Atlanta-based fintech VC (founded 2000); invests in financial services and financial-product companies serving the sector and consumers. Sign in to see full profile →
Big Idea Ventures
Looking at companies from pre-product to those that have recurring revenue Sign in to see full profile →
S.R. One
Trans-Atlantic biotech venture capital firm (former GSK venture arm); offices in San Francisco and London; $600M Fund II. Sign in to see full profile →
Amgen Ventures
Corporate venture arm of Amgen (since 2004); early-stage biotech investments in oncology, inflammation, neuroscience, cardiovascular. Sign in to see full profile →
Foothill Ventures
Silicon Valley seed-stage deep-tech VC (rebranded from Tsingyuan Ventures to Foothill Ventures in 2021); invests in software, life science and frontier hard … Sign in to see full profile →
Greenoaks
Greenoaks is a San Francisco investment firm, founded in 2012 by Neil Mehta and Benny Peretz, that makes concentrated, long-term investments in technology-en… Sign in to see full profile →
IBM Ventures
IBM's $500M+ corporate venture arm backing early-stage AI, quantum, security, data, sustainability startups. Sign in to see full profile →
Streamlined Ventures
Palo Alto-based solo-GP seed VC (founded 2013 by Ullas Naik) backing software companies in AI, data science, automation, APIs, blockchain and gaming. Sign in to see full profile →
Propeller
Climate-tech VC (founded 2022 by HubSpot's Brian Halligan) investing $500K-$2M in ocean-climate startups including shipping, offshore wind, wave energy, desa… Sign in to see full profile →
TPG
TPG is a global alternative asset manager founded in San Francisco in 1992 by Jim Coulter and David Bonderman, with $327B in assets under management. Sign in to see full profile →
Deviation Capital
Early-stage VC (Seed and Series A) backing technical founders building data- and compute-native companies; ~$2B AUM, offices in New York and San Francisco; e… Sign in to see full profile →
Climate Pledge Fund
Amazon's $2B corporate venture program investing in companies accelerating decarbonisation and the company's path to The Climate Pledge. Sign in to see full profile →
Creative Ventures
Looking at companies from pre-product to those that have shown product-market fit Sign in to see full profile →
Emerald Development Manager
New York-based early-stage VC backing elite scientific/engineering teams in cybersecurity/SaaS, biotech/healthcare IT, and clean tech/industrial tech. Sign in to see full profile →
Red Cedar Ventures
Venture subsidiary of the MSU Research Foundation supporting early-stage high-tech startups emerging from Michigan State University. Sign in to see full profile →
Valar Ventures
Manhattan-based VC co-founded by Peter Thiel, Andrew McCormack and James Fitzgerald in 2010; focuses on international fintech outside Silicon Valley (Wise, N… Sign in to see full profile →
Hearst Ventures
Corporate VC arm of Hearst Communications (since 1995) investing in media, information, and technology. Sign in to see full profile →
Citi Ventures
Citi's venture arm, investing in and partnering with startups transforming financial services, from seed to Series F and beyond, across fintech, AI and data,… Sign in to see full profile →
Leawood Venture Capital
Leawood Kansas-based early-stage VC investing in technology companies across the US since 2017. Sign in to see full profile →
Directory last updated: September 2026.
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