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VC Firms in San Francisco

We've mapped 16 of the most active VC firms in San Francisco, with cheques $70K–$300M.

We've mapped 16 of the most active VC firms investing in San Francisco — ranked by how recently and how thoroughly each profile has been verified. Cheque sizes across this segment run $70K–$300M.

Not every one of these VC firms is a fit for every round — they differ on stage, cheque size, and sector focus, and the best-known name is rarely the best match. 16 of these profiles have been verified in the last review pass. Sign in to see each investor's full thesis, cheque range, and how closely they fit your specific company.

VC
Verified Sep 2026

Creative Ventures

Seed
🇺🇸US
AI/MLAR/VRBiotech+7 more

Looking at companies from pre-product to those that have shown product-market fit Sign in to see full profile →

VC
Verified May 2026
Greenoaks logo

Greenoaks

Seed · Series A · Series B · Later
🇺🇸US
AI/MLConsumerSaaS+3 more

Greenoaks is a San Francisco investment firm, founded in 2012 by Neil Mehta and Benny Peretz, that makes concentrated, long-term investments in technology-en… Sign in to see full profile →

VC
Verified May 2026
11.2 Capital logo

11.2 Capital

Seed · Series A
🇺🇸US
AI/MLBiotechCyber+5 more

Early-stage VC investing in breakthrough deep tech: AI, cybersecurity, quantum, robotics, new space, bioengineering, climate. Sign in to see full profile →

VC
Verified May 2026
S.R. One logo

S.R. One

Seed · Series A · Series B
🇺🇸US
Biotech

Trans-Atlantic biotech venture capital firm (former GSK venture arm); offices in San Francisco and London; $600M Fund II. Sign in to see full profile →

VC
Verified May 2026
M12 logo

M12

Seed · Series A · Series B · Later
🇺🇸US
AI/MLCyberDeeptech+3 more

Invests in: Europe, Israel, USA Sign in to see full profile →

VC
Verified May 2026
Citi Ventures logo

Citi Ventures

Seed · Series A · Series B · Later
🇺🇸US
AI/MLWeb3Cyber+3 more

Writes checks from $1M - $10M+ Sign in to see full profile →

VC
Verified Sep 2026
AgFunder logo

AgFunder

Seed · Series A · Series B
🇺🇸US
BiotechFood & AgHealthtech+1 more

Bay Area VC investing in agrifoodtech and deeptech startups; $170M AUM, pre-seed to Series A. Sign in to see full profile →

VC
Verified Sep 2026
Congruent Ventures logo

Congruent Ventures

Pre-seed · Seed · Series A
🇺🇸US
AI/MLClimateConsumer+6 more

Co-Invest — Looking at companies from the idea stage to those that 500K+ in MRR Sign in to see full profile →

VC
Verified Sep 2026
DBL Partners logo

DBL Partners

Series A · Series B
🇺🇸US
AI/MLClimateFood & Ag+3 more

Invests in: USA We invest in companies that can deliver top-tier venture capital returns and enable social, environmental and economic benefits. Sign in to see full profile →

VC
Verified Sep 2026
Fifty Years logo

Fifty Years

Pre-seed · Seed
🇺🇸US
AI/MLBiotechClimate+5 moreGeneralist

Lead, Co-Invest — Looking at companies from the idea stage to 500K+ in MRR Sign in to see full profile →

VC
Verified Sep 2026
Future Ventures logo

Future Ventures

Pre-seed · Seed · Series A · Series B
🇺🇸US
AI/MLBiotechClimate+10 moreGeneralist

Future Ventures is a US venture capital firm founded in 2018 by Steve Jurvetson and Maryanna Saenko that invests at seed and early stage in mission-driven fr… Sign in to see full profile →

VC
Verified Sep 2026
Green Bay Ventures logo

Green Bay Ventures

Seed · Series A · Series B
🇺🇸US
AI/MLClimateFintech+3 more

Green Bay Ventures is a San Francisco-based venture capital firm founded in 2012 by NEA co-founder C. Sign in to see full profile →

VC
Verified Sep 2026

MHS Capital

Seed · Series A
🇺🇸US
ConsumerSaaSFintech

San Francisco-based early-stage venture capital firm (founded 2006) backing bootstrapped software and internet companies with demonstrated traction transitio… Sign in to see full profile →

VC
Verified Sep 2026
Prelude Ventures logo

Prelude Ventures

Pre-seed · Seed · Series A · Series B · Later
🇺🇸US
AI/MLBiotechClimate+7 more

Invests in: USA Prelude Ventures invests in and supports early-stage startups with the greatest potential to mitigate climate change. Sign in to see full profile →

VC
Verified Sep 2026
PsyMed Ventures logo

PsyMed Ventures

Pre-seed · Seed · Series A · Series B · Later
🇺🇸US
AI/MLBiotechHealthtech

$25M frontier brain and mental health VC (founded 2020) investing pre-seed to Series C across psychedelic medicine, neurotechnology, precision psychiatry, di… Sign in to see full profile →

VC
Verified May 2026
Ultra Capital logo

Ultra Capital

Pre-seed · Seed
🇺🇸US
ClimateFood & AgIndustrial+1 more

Ultra Capital is a San Francisco-based investment firm financing small to mid-size distributed sustainable infrastructure projects across agriculture, energy… Sign in to see full profile →

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Directory last updated: September 2026