Seed B2B SaaS Investors in San Francisco
We've mapped 18 of the most active seed B2B SaaS investors funding founders in San Francisco, with cheques $50K–$300M.
- Pre-seed9
- Seed18
- Series A15
- Series B11
- Series C+7
We've mapped 18 of the most active seed B2B SaaS investors funding founders in San Francisco — 18 VCs. Cheque sizes across this segment run $50K–$300M.
When raising seed for a B2B SaaS company in San Francisco, founders should lead with the investors whose stage and cheque size actually match the round — not just the best-known names. 18 of these profiles have been verified in the last review pass. Sign in to see each investor's full thesis, cheque range, and how closely they fit your specific company.
M12
Microsoft's venture capital fund, investing in seed through Series B companies in AI apps, security for AI, AI cloud infrastructure, AI data ops and models, … Sign in to see full profile →
Greenoaks
Greenoaks is a San Francisco investment firm, founded in 2012 by Neil Mehta and Benny Peretz, that makes concentrated, long-term investments in technology-en… Sign in to see full profile →
Citi Ventures
Citi's venture arm, investing in and partnering with startups transforming financial services, from seed to Series F and beyond, across fintech, AI and data,… Sign in to see full profile →
Creative Ventures
Looking at companies from pre-product to those that have shown product-market fit Sign in to see full profile →
First Round Capital
First Round Capital is a US seed-stage venture firm founded in 2004 by Josh Kopelman and Howard Morgan, with offices in San Francisco (HQ), New York and Phil… Sign in to see full profile →
Salesforce Ventures
Salesforce Ventures is the venture arm of Salesforce, based in San Francisco, investing in enterprise technology companies from seed through growth since 2009. Sign in to see full profile →
SV Angel
San Francisco angel firm founded by Ron Conway investing in 100+ early-stage AI/software/IT startups per year; portfolio includes Facebook, Twitter, Airbnb, … Sign in to see full profile →
DCVC
DCVC (Data Collective) is a deep-tech venture capital firm founded in 2010 by Matt Ocko and Zachary Bogue, with offices in Palo Alto and San Francisco. Sign in to see full profile →
SignalFire
San Francisco-based AI-native VC with ~$3bn AUM, investing pre-seed to Series B in applied AI across healthcare, cybersecurity, infra, consumer and enterprise. Sign in to see full profile →
South Park Commons
San Francisco-based community for founders and technologists exploring what to build, with spaces in San Francisco, New York and Bengaluru. Sign in to see full profile →
Founders Fund
Founders Fund is a San Francisco venture capital firm founded in 2005 by Peter Thiel, Ken Howery and Luke Nosek. Sign in to see full profile →
Headline
Global VC (formerly e.ventures) with teams in the US, Europe, Asia, and Brazil; invests across fintech, e-commerce, software, digital health, and consumer. Sign in to see full profile →
Base10 Partners
San Francisco-based early-stage VC ($1.3B AUM) backing automation in finance, food, healthcare, retail, logistics and construction. Sign in to see full profile →
Conviction Partners
AI-native venture firm (Software 3.0) founded 2022 by Sarah Guo. Sign in to see full profile →
Benchmark
Benchmark is an early-stage venture capital firm founded in 1995 and headquartered in San Francisco (with a Woodside, CA office) that typically leads the fir… Sign in to see full profile →
CRV
CRV (formerly Charles River Ventures) - top-tier early-stage VC since 1970, ~$1.5B AUM, 600+ investments including DoorDash, Airtable, Patreon, Drift. Sign in to see full profile →
Homebrew
Hands-on founder-friendly pre-seed and seed-stage fund founded by Hunter Walk and Satya Patel; portfolio includes Chime, Plaid, Gusto, ShieldAI, Cruise. Sign in to see full profile →
Initialized Capital
Seed-stage VC with offices in San Francisco and New York, backing founders across enterprise SaaS, sustainability, health, hard tech, AI, infrastructure, con… Sign in to see full profile →
Directory last updated: November 2026.
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